• Nature
  • Amino Acid Sequence
    • Species
    • Sequence
    • Amino acids
      213 to 225

Associated products


Our Abpromise guarantee covers the use of ab22776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SOCS3 antibody (ab723)

  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • ATOD4
    • CIS 3
    • CIS-3
    • CIS3
    • Cish3
    • Cytokine induced SH2 protein 3
    • Cytokine-inducible SH2 protein 3
    • E2a Pbx1 target gene in fibroblasts 10
    • EF 10
    • MGC71791
    • SOCS 3
    • SOCS-3
    • Socs3
    • SSI 3
    • SSI-3
    • SSI3
    • STAT induced STAT inhibitor 3
    • STAT-induced STAT inhibitor 3
    • Suppressor of cytokine signaling 3
    see all
  • Function
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
  • Tissue specificity
    Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
  • Pathway
    Protein modification; protein ubiquitination.
  • Involvement in disease
    Note=There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients.
  • Sequence similarities
    Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • Domain
    The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Post-translational
    Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.
  • Information by UniProt


ab22776 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


Thank you for getting back in touch with me. Both SOCS1 antibody (ab3691) Rabbit Polyclonal IgG and SOCS3 antibody [SO1] (ab14939) Mouse Monoclonal IgG2b require secondary antibodies for the detection as neither are directly conjugated with fluorescence. There are compatible secondaries at the bottom of each datasheet (dependent on the application). It may also be useful if you look at our available secondary antibodies by hovering on our product browsed and moving across into mouse or rabbit and then IgG. As you see there are many secondary antibodies available. Whilst they are not advertised as so I think that SOCS1 peptide (199-211) (ab23167) is certainly suitable as a positive control standard for ab3691. Unfortunately ab14939 was raised using full length recombinant protein. Therefore I consider it possible that the antibody will not recognise SOCS3 peptide (213-225)(ab22776) with great efficiency given a possibility that the mixture of immunoglobulins does not target this peptide. I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

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