The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
< 1.000 Eu/µg
>95% by SDS-PAGE .
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 7.40 Constituents: 95% PBS, 5% Trehalose
Lyophilized from 0.22 µm filtered solution.
It is recommended to reconstitute the lyophilized protein in sterile deionized water to a final concentration of 1mg/ml. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% HSA or BSA) is strongly recommended for further dilution and long term storage.
Manganese containing superoxide dismutase
Manganese superoxide dismutase
Mangano superoxide dismutase
Mn superoxide dismutase
Superoxide dismutase [Mn] mitochondrial
Superoxide dismutase [Mn], mitochondrial
Superoxide dismutase 2 mitochondrial
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Involvement in disease
Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Belongs to the iron/manganese superoxide dismutase family.
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.