Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab199552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-TOP3B antibody [EP7779] - C-terminal (ab183520)

  • Form

    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • DNA topoisomerase 3 beta 1
    • DNA topoisomerase 3-beta-1
    • DNA topoisomerase III beta 1
    • DNA topoisomerase III beta-1
    • FLJ39376
    • TOP 3B
    • TOP3B
    • TOP3B_HUMAN
    • TOP3B1
    • Topo III beta
    • Topoisomerase (DNA) III beta
    • Topoisomerase DNA III beta
    • Topoisomerase III beta
    see all
  • Function

    Possesses negatively supercoiled DNA relaxing activity.
  • Tissue specificity

    Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
  • Sequence similarities

    Belongs to the prokaryotic type I/III topoisomerase family.
    Contains 1 Toprim domain.
  • Information by UniProt

References

ab199552 has not yet been referenced specifically in any publications.

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