Product nameHuman USP14/TGT peptide
See all USP14/TGT proteins and peptides
Amino Acid Sequence
Amino acids2 to 14
Our Abpromise guarantee covers the use of ab23055 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This product was previously labelled as USP14
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Deubiquitinating enzyme 14
- tRNA guanine transglycosylase
FunctionProteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Sequence similaritiesBelongs to the peptidase C19 family. USP14/UBP6 subfamily.
Contains 1 ubiquitin-like domain.
Cellular localizationCytoplasm. Cell membrane.
- Information by UniProt
ab23055 has not yet been referenced specifically in any publications.