Overview

  • Product name

  • Description

    Rabbit polyclonal to HYAL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Rat HYAL1 aa 270-320 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    T GKSQMYVRYR VQEAFRLALV SRDPHVPIMP YVQIFYEKTD YLLPLEELEH


    Database link: Q76HN1

  • Positive control

    • Human colon carcinoma tissue; Human hepatoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab203293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Use at 1/50 - 1/200 with fluorescent detection methods.

WB 1/100 - 1/1000. Predicted molecular weight: 48 kDa.

Target

  • Function

    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • Tissue specificity

    Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
  • Involvement in disease

    Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
  • Sequence similarities

    Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.
  • Cellular localization

    Secreted. Lysosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • HYAL 1 antibody
    • Hyal-1 antibody
    • HYAL1 antibody
    • HYAL1_HUMAN antibody
    • Hyaluronidase 1 antibody
    • Hyaluronidase-1 antibody
    • Hyaluronoglucosaminidase 1 antibody
    • Hyaluronoglucosaminidase-1 antibody
    • Hyaluronoglucosaminidase1 antibody
    • LUCA 1 antibody
    • LUCA-1 antibody
    • LUCA1 antibody
    • Lung carcinoma protein 1 antibody
    • MGC45987 antibody
    • NAT6 antibody
    • Plasma hyaluronidase antibody
    • Tumor suppressor LUCA 1 antibody
    see all

Images

  • Immunohistochemistry analysis of Formalin-fixed, paraffin embedded Human hepatoma tissue labeling HYAL1 with ab203293 at 1/100 dilution, followed by secondary detection and DAB staining.

  • Immunohistochemistry analysis of Formalin-fixed, paraffin embedded Human colon carcinoma tissue labeling HYAL1 with ab203293 at 1/300 dilution, followed by secondary detection and DAB staining.

References

ab203293 has not yet been referenced specifically in any publications.

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