• Product name
  • Description
    Rabbit polyclonal to HYAL1
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human HYAL1.

  • Positive control
    • This antibody gave a positive signal in the following Human tissue lysates: Liver; Kidney; Heart; Breast.



Our Abpromise guarantee covers the use of ab96751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 45 kDa (predicted molecular weight: 48 kDa).


  • Function
    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • Tissue specificity
    Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
  • Involvement in disease
    Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
  • Sequence similarities
    Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.
  • Cellular localization
    Secreted. Lysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • HYAL 1 antibody
    • Hyal-1 antibody
    • HYAL1 antibody
    • HYAL1_HUMAN antibody
    • Hyaluronidase 1 antibody
    • Hyaluronidase-1 antibody
    • Hyaluronoglucosaminidase 1 antibody
    • Hyaluronoglucosaminidase-1 antibody
    • Hyaluronoglucosaminidase1 antibody
    • LUCA 1 antibody
    • LUCA-1 antibody
    • LUCA1 antibody
    • Lung carcinoma protein 1 antibody
    • MGC45987 antibody
    • NAT6 antibody
    • Plasma hyaluronidase antibody
    • Tumor suppressor LUCA 1 antibody
    see all


  • All lanes : Anti-HYAL1 antibody (ab96751) at 1 µg/ml

    Lane 1 : Human liver tissue lysate - total protein (ab29889)
    Lane 2 : Human kidney tissue lysate - total protein (ab30203)
    Lane 3 : Human heart tissue lysate - total protein (ab29431)
    Lane 4 : Human breast tissue lysate - total protein (ab30090)

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 48 kDa
    Observed band size: 45 kDa (why is the actual band size different from the predicted?)
    Additional bands at: 60 kDa. We are unsure as to the identity of these extra bands.

    Exposure time: 4 minutes

    The band observed at 45 kDa could potentially be a cleaved form of HYAL1 due to the presence of a 21 amino acid signal peptide.


ab96751 has not yet been referenced specifically in any publications.

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