• Product name

    Anti-HYAL1 antibody [EPR5542]
    See all HYAL1 primary antibodies
  • Description

    Rabbit monoclonal [EPR5542] to HYAL1
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human HYAL1 aa 350 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: Q12794

  • Positive control

    • HepG2, LnCap and HT-1376 cell lysates.
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab180143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa).


  • Function

    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • Tissue specificity

    Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
  • Involvement in disease

    Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
  • Sequence similarities

    Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.
  • Cellular localization

    Secreted. Lysosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • HYAL 1 antibody
    • Hyal-1 antibody
    • HYAL1 antibody
    • HYAL1_HUMAN antibody
    • Hyaluronidase 1 antibody
    • Hyaluronidase-1 antibody
    • Hyaluronoglucosaminidase 1 antibody
    • Hyaluronoglucosaminidase-1 antibody
    • Hyaluronoglucosaminidase1 antibody
    • LUCA 1 antibody
    • LUCA-1 antibody
    • LUCA1 antibody
    • Lung carcinoma protein 1 antibody
    • MGC45987 antibody
    • NAT6 antibody
    • Plasma hyaluronidase antibody
    • Tumor suppressor LUCA 1 antibody
    see all


  • All lanes : Anti-HYAL1 antibody [EPR5542] (ab180143) at 1/1000 dilution

    Lane 1 : HepG2 cell lysate
    Lane 2 : LnCap cell lysate
    Lane 3 : HT-1376 cell lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

    Predicted band size: 48 kDa
    Observed band size: 60 kDa
    why is the actual band size different from the predicted?

    Blocking buffer and concentration: 5%NFDM/TBST


ab180143 has not yet been referenced specifically in any publications.

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