Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor (ab141566)

Overview

  • Product name

    Hydroxy-2-naphthalenylmethylphosphonic acid (HNMPA), Insulin receptor tyrosine kinase inhibitor
  • Description

    Insulin receptor tyrosine kinase inhibitor
  • Biological description

    Insulin receptor tyrosine kinase inhibitor (IC50 = 100 µM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor. Membrane impermeable (membrane permeable analog available ab141567).
  • Purity

    > 98%
  • CAS Number

    120943-99-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Moon MJ  et al. Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. Mol Cells 32:389-95 (2011). Read more (PubMed: 21904878) »
  • Baltensperger K  et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A 89:7885-9 (1992). Read more (PubMed: 1381504) »
  • Saperstein R  et al. Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells. Biochemistry 28:5694-701 (1989). Read more (PubMed: 2550060) »

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