Cholinesterase inhibitor. Potential Alzheimer’s therapeutic of low toxicity. Bioactive monohydroxylated metabolite of tacrine with similar anticholinesterase activity, but displays less acute toxicity in animals. Inhibits Acetylcholine esterase.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in water to 10 mM (with warming), in DMSO to 75 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Hansen LL et al. Determination of tacrine and its metabolites in human plasma and urine by high-performance liquid chromatography and fluorescence detection. J Chromatogr B Biomed Sci Appl712:183-91 (1998).
Read more (PubMed: 9698241) »
Shutske GM et al. 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics. J Med Chem32:1805-13 (1989).
Read more (PubMed: 2754707) »
Shutske GM et al. (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity. J Med Chem31:1278-9 (1988).
Read more (PubMed: 3385720) »