Product nameHyoscyamine, Muscarinic acetylcholine receptor antagonist
DescriptionCompetitive, non-selective muscarinic acetylcholine receptor antagonist
- (S)-(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
Levorotary isomer of atropine (ab145582). Competitive, non-selective muscarinic acetylcholine receptor antagonist. Blocks the action of acetylcholine at parasympathetic sites in sweat glands, salivary glands, stomach secretions, heart muscle, sinoatrial node, smooth muscle in the gastrointestinal tract, and the central nervous system.
Chemical name[(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
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This product has been referenced in:
- Schmeller T et al. Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors. Pharmazie 50:493-5 (1995). Read more (PubMed: 7675895) »
- Vogel WK et al. Porcine m2 muscarinic acetylcholine receptor-effector coupling in Chinese hamster ovary cells. J Biol Chem 270:15485-93 (1995). Read more (PubMed: 7797541) »
- Grynkiewicz G & Gadzikowska M Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. Pharmacol Rep 60:439-63 (0). Read more (PubMed: 18799813) »