Overview

  • Product name

    Hypericin, PKC inhibitor
  • Description

    Selective PKC inhibitor. Antiviral agent.
  • Biological description

    Selective PKC inhibitor (IC50 = 3.3 μM). Antiviral agent. Potent tyrosine kinase inhibitor (IC50 = 7.5 μM). Potent CKII inhibitor (IC50 = 6 nM). Inactivates enveloped viruses including HIV. Promotes VEGF and TGF-β production. Shows photosensitizing and antidepressant effects in vivo.
  • Purity

    > 97%
  • CAS Number

    548-04-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
  • Molecular weight

    504.44
  • Molecular formula

    C30H16O8
  • PubChem identifier

    5281051
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 10 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
  • Source

    Hypericum perforatum

  • Research areas

References

This product has been referenced in:

  • Laffers W  et al. Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro. Eur Arch Otorhinolaryngol : (2014). Read more (PubMed: 24687800) »
  • Sayar H  et al. Comparison of efficacy of topical phenytoin with hypericin in second-degree burn wound healing: an experimental study in rats. Med Sci Monit Basic Res 20:36-46 (2014). Read more (PubMed: 24694757) »
  • Kubin A  et al. Hypericin--the facts about a controversial agent. Curr Pharm Des 11:233-53 (2005). Read more (PubMed: 15638760) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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