Overview

  • Product name

    Hypocrellin A, PKC inhibitor
  • Description

    Potent PKC inhibitor. Photosensitizing agent.
  • Biological description

    Potent PKC inhibitor. Photosensitizing agent. Potent antileishmanial agent. Selective class II-MHC restricted presentation of exogenous antigen inhibitor. Shows antitumor, antifungal and antiviral effects in vivo.
  • Purity

    > 77%
  • CAS Number

    77029-83-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,2R)-1-Acetyl-2,5,12-trihydroxy-4,8,9,13-tetramethoxy-2-methyl-2,3-dihydro-1H-cyclohepta[ghi]perylene-6,11-dione
  • Molecular weight

    546.52
  • Molecular formula

    C30H26O10
  • PubChem identifier

    119305
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)C1C2=C(C(=C3C(=O)C=C(C4=C5C(=CC(=O)C6=C(C(=C(CC1(C)O)C(=C56)C2=C43)OC)O)OC)OC)O)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xie W  et al. Spectroscopic studies on the interaction of Ga3+-hypocrellin A with myoglobin. Spectrochim Acta A Mol Biomol Spectrosc 121:109-15 (2014). Read more (PubMed: 24231746) »
  • Park S  et al. Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing. Immune Netw 11:412-5 (2011). Read more (PubMed: 22346783) »
  • Ma G  et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother 48:4450-2 (2004). Read more (PubMed: 15504880) »

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