Overview

  • Product name

    Hypothemycin, MEK inhibitor
  • Description

    Potent, selective MEK inhibitor. Antiproliferative agent.
  • Biological description

    Potent, selective MEK inhibitor. Antiproliferative agent. Reduces expression of Ras-inducible genes (MMP-1, MMP-9, TGF-β and VEGF). Inhibits growth of cancer cell lines (IC50 values are 78 and 900 μM for HT29 and HCT116 respectively). Shows antifungal effects in vivo.
  • Purity

    > 98%
  • CAS Number

    76958-67-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Nishino M  et al. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife 2:e00712 (2013). Read more (PubMed: 23853713) »
  • Xu L  et al. Antifungal activity of hypothemycin against Peronophythora litchii in vitro and in vivo. J Agric Food Chem 61:10091-5 (2013). Read more (PubMed: 24106914) »
  • Tanaka H  et al. Antitumor efficacy of hypothemycin, a new Ras-signaling inhibitor. Jpn J Cancer Res 90:1139-45 (1999). Read more (PubMed: 10595743) »
See 1 Publication for this product

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