I-BET151, pan-BET family inhibitor (ab230362)

Overview

  • Product name

    I-BET151, pan-BET family inhibitor
  • Description

    An isoxazole class pan-BET family inhibitor.
  • Alternative names

    • GSK1210151A
  • Biological description

    I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3 and BRD4 with IC50 values of 0.5, 0.25 and 0.79 µM, respectively. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.

  • Purity

    > 98%
  • CAS Number

    1300031-49-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one
  • Molecular weight

    415.50
  • Molecular formula

    C23H21N5O3
  • PubChem identifier

    52912189
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Handling

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(ON=C1C)=C1C2=CC(N=CC(N3)=C4N([C@H](C)C5=CC=CC=N5)C3=O)=C4C=C2OC
  • Source

    Synthetic

References

This product has been referenced in:

  • Gallenkamp D  et al. Bromodomains and their pharmacological inhibitors. ChemMedChem 9:438-64 (2014). Read more (PubMed: 24497428) »
  • Vidler LR  et al. Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites. J Med Chem 55:7346-59 (2012). Read more (PubMed: 22788793) »
  • Kline TB  et al. Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives. J Med Chem 25:1381-3 (1982). Read more (PubMed: 6815326) »

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