• Product name

  • Description

    Rabbit polyclonal to IB-2
  • Host species

  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment corresponding to Human IB-2 aa 529-804.
    Database link: Q13387

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, Molt4, Raji and mouse brain whole cell lysates; HeLa cells.
  • General notes

    Previously labelled as JIP2. 



Our Abpromise guarantee covers the use of ab154090 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 88 kDa.
ICC/IF 1/100 - 1/1000.


  • Function

    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.
  • Tissue specificity

    Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.
  • Sequence similarities

    Belongs to the JIP scaffold family.
    Contains 1 PID domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cytoplasm. Accumulates in cell surface projections.
  • Information by UniProt
  • Database links

  • Alternative names

    • C jun amino terminal kinase interacting protein 2 antibody
    • C-jun-amino-terminal kinase-interacting protein 2 antibody
    • Homologous to mouse JIP 1 antibody
    • IB 2 antibody
    • IB-2 antibody
    • IB2 antibody
    • Islet brain 2 antibody
    • Islet-brain-2 antibody
    • JIP 2 antibody
    • JIP-2 antibody
    • JIP2 antibody
    • JIP2_HUMAN antibody
    • JNK interacting protein 2 antibody
    • JNK MAP kinase scaffold protein 2 antibody
    • JNK MAP kinase scaffold protein JIP2 antibody
    • JNK-interacting protein 2 antibody
    • MAPK8IP2 antibody
    • Mitogen activated protein kinase 8 interacting protein 2 antibody
    • Mitogen-activated protein kinase 8-interacting protein 2 antibody
    • PRKM8 interacting protein like antibody
    • PRKM8IPL antibody
    see all


  • Anti-IB-2 antibody (ab154090) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg

    Predicted band size: 88 kDa

    7.5% SDS PAGE
  • Anti-IB-2 antibody (ab154090) at 1/1000 dilution + mouse brain whole cell lysate at 50 µg

    Predicted band size: 88 kDa

    7.5% SDS PAGE
  • Immunofluorescence analysis of methanol-fixed HeLa cells labeling IB-2 with ab154090 at 1/200 dilution. The image in the lower panel is costained with Hoechst 33342.


This product has been referenced in:

  • Haidar M  et al. miR-126-5p by direct targeting of JNK-interacting protein-2 (JIP-2) plays a key role in Theileria-infected macrophage virulence. PLoS Pathog 14:e1006942 (2018). Read more (PubMed: 29570727) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab154090.
Please use the links above to contact us or submit feedback about this product.

For licensing inquiries, please contact partnerships@abcam.com

Sign up