Overview

  • Product name

  • Description

    Rabbit polyclonal to IB-2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human IB-2 aa 470-570.
    Sequence:

    EEDEEDDEEEEDAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHT QLELVSLRRCAGLGHDSEEDSGGEASEEEAGAALLGGGQVSGDTSPDSPD L


    Database link: Q13387

  • Positive control

    • WB: U-251 MG and A549 whole cell lysate.
  • General notes

    Previously labelled as JIP2. 

Properties

Applications

Our Abpromise guarantee covers the use of ab234658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 87 kDa.

Target

  • Function

    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.
  • Tissue specificity

    Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.
  • Sequence similarities

    Belongs to the JIP scaffold family.
    Contains 1 PID domain.
    Contains 1 SH3 domain.
  • Cellular localization

    Cytoplasm. Accumulates in cell surface projections.
  • Information by UniProt
  • Database links

  • Alternative names

    • C jun amino terminal kinase interacting protein 2 antibody
    • C-jun-amino-terminal kinase-interacting protein 2 antibody
    • Homologous to mouse JIP 1 antibody
    • IB 2 antibody
    • IB-2 antibody
    • IB2 antibody
    • Islet brain 2 antibody
    • Islet-brain-2 antibody
    • JIP 2 antibody
    • JIP-2 antibody
    • JIP2 antibody
    • JIP2_HUMAN antibody
    • JNK interacting protein 2 antibody
    • JNK MAP kinase scaffold protein 2 antibody
    • JNK MAP kinase scaffold protein JIP2 antibody
    • JNK-interacting protein 2 antibody
    • MAPK8IP2 antibody
    • Mitogen activated protein kinase 8 interacting protein 2 antibody
    • Mitogen-activated protein kinase 8-interacting protein 2 antibody
    • PRKM8 interacting protein like antibody
    • PRKM8IPL antibody
    see all

Images

  • All lanes : Anti-IB-2 antibody (ab234658) at 1/1000 dilution

    Lane 1 : U-251 MG (Human brain glioma cell line) whole cell lysate
    Lane 2 : A549 (Human lung carcinoma cell line) whole cell lysate

    Secondary
    All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution

    Predicted band size: 87 kDa

References

ab234658 has not yet been referenced specifically in any publications.

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