Key features and details
- Highly potent and selective A3 agonist
- CAS Number: 152918-18-8
- Purity: > 97%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameIB-MECA, A3 agonist
DescriptionHighly potent and selective A3 agonist
Highly potent and selective A3 agonist (Ki values are 1.1, 12.6 and 56 nM at A3, A1 and A2A receptors, respectively). Produces potent cardioprotective effects against myocardial injury. Mediates suppression of melanoma cells and suppresses human breast cancer cell proliferation.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120438 has been referenced in 2 publications.
- Qu F et al. Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine3 receptor. J Cell Physiol 235:2441-2451 (2020). PubMed: 31556103
- Yi X et al. Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells. Biochem Biophys Res Commun 497:850-856 (2018). PubMed: 29454963