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Biochemicals Product Range Just Add Water
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Iberiotoxin, high-conductance K+ channel blocker  (ab120379)

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  • SDS
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Functional Studies - Iberiotoxin, high-conductance K<sup>+</sup> channel blocker&nbsp; (ab120379)

    Key features and details

    • Selective blocker of the high-conductance, Ca2+-activated K+ channel
    • CAS Number: 129203-60-7
    • Purity: > 95%
    • Soluble in water
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Iberiotoxin, high-conductance K+ channel blocker 
    • Description

      Selective blocker of the high-conductance, Ca2+-activated K+ channel
    • Biological description

      Selective blocker of the high-conductance, Ca2+-activated K+ channel. Originally isolated from the scorpion Mesobuthus tamulus. Specifically blocks KCa1.1 (Slo) channels (Ki approx. 1 nM).

    • Purity

      > 95%
    • CAS Number

      129203-60-7
    • Chemical structure

      Chemical Structure

    Properties

    • Molecular weight

      4230.86
    • Molecular formula

      C179H274N50O55S7
    • Sequence

      XFTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ (Modifications: X-1 = Glp; Disulfide bonds: 7-28, 13-33, 17-35)
    • PubChem identifier

      16132435
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in water
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • Source

      Synthetic

    • Research areas

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    Images

    • Functional Studies - Iberiotoxin, high-conductance K<sup>+</sup> channel blocker&nbsp; (ab120379)
      Functional Studies - Iberiotoxin, high-conductance K+ channel blocker  (ab120379)

      HEK293 cells plated for 48 hours and then transfected with rat Slo27 for 24 hours. Currents from whole-cell recordings, with 1 µM Ca2+ in the electrode solution. Cells voltage-clamped at -80 mV, with currents activated by 500 ms depolarization to +20 mV. Concentration-inhibition relationship produces an IC50 of 412 pM.

      (Number of experimental determinations shown in brackets).

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (4)

    Publishing research using ab120379? Please let us know so that we can cite the reference in this datasheet.

    ab120379 has been referenced in 4 publications.

    • Wang M  et al. Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide. Biomed Res Int 2018:2925985 (2018). PubMed: 29511675
    • Fleck D  et al. Distinct purinergic signaling pathways in prepubescent mouse spermatogonia. J Gen Physiol 148:253-71 (2016). PubMed: 27574293
    • Umatani C  et al. GnRH suppresses excitability of visual processing neurons in the optic tectum. J Neurophysiol 114:2775-84 (2015). PubMed: 26354319
    • Hartung H  et al. Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens. Neuropsychopharmacology 36:1811-22 (2011). PubMed: 21508928

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