Key features and details
- Non-selective PDE inhibitor. Anti-inflammatory agent.
- CAS Number: 50847-11-5
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameIbudilast, PDE inhibitor
DescriptionNon-selective PDE inhibitor. Anti-inflammatory agent.
Non-selective PDE inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Anti-inflammatory agent. Inhibits platelet aggregation. Centrally active via glial cell attenuation. Shows bronchodilatory, vasodilatory and neuroprotective effects in vivo. Orally active. Blood-brain barrier permeable.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab143333 has not yet been referenced specifically in any publications.