Key features and details
- Selective CK1δ and CK1ε inhibitor. Potent microtubulin polymerization inhibitor.
- CAS Number: 186611-52-9
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameIC 261, CK1delta and CK1epsilon inhibitor
DescriptionSelective CK1δ and CK1ε inhibitor. Potent microtubulin polymerization inhibitor.
Selective CK1δ and CK1ε inhibitor. Potent microtubulin polymerization inhibitor. Induces cell cycle arrest and apoptosis. Selectively inhibits tumor cells growth. Shows antitumor effects in vivo.
Storage instructionsStore at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145189 has been referenced in 1 publication.
- Tsukiyama T et al. A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis. Nat Commun 11:4586 (2020). PubMed: 32934222