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    icad-antibody-ab2040.pdf

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Cell Biology Apoptosis Nucleus DNAses
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Anti-ICAD antibody (ab2040)

  • Datasheet
  • SDS
Submit a review Submit a question References (1)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAD antibody (ab2040)
  • Western blot - Anti-ICAD antibody (ab2040)

Key features and details

  • Rabbit polyclonal to ICAD
  • Suitable for: IHC-P, WB
  • Reacts with: Mouse
  • Isotype: IgG

You may also be interested in

Protein
Recombinant Human ICAD protein (ab173052)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-ICAD antibody
    See all ICAD primary antibodies
  • Description

    Rabbit polyclonal to ICAD
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    IHC-P
    Mouse
    WB
    Mouse
    See all applications and species data
  • Immunogen

    Synthetic peptide, corresponding to amino acids 312-331 of Mouse ICAD (CT).

  • Positive control

    • Mouse lung tissue lysate.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C. The product can be stored for up to 12 months.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Apoptosis
    • Nucleus
    • DNAses
    • Epigenetics and Nuclear Signaling
    • Cell cycle
    • Apoptosis
    • Nuclear
    • Metabolism
    • Pathways and Processes
    • Metabolism processes
    • Apoptosis
    • Cancer
    • Cell Death
    • Apoptosis
    • Nucleus
    • DNAses
    • Cancer
    • Cell Death
    • Apoptosis
    • Metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human ICAD protein (ab173052)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab2040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
IHC-P
Mouse
WB
Mouse
Application Abreviews Notes
IHC-P
Use at an assay dependent concentration.
WB
1/500 - 1/2000. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).
Notes
IHC-P
Use at an assay dependent concentration.
WB
1/500 - 1/2000. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).

Target

  • Function

    Inhibitor of the caspase-activated DNase (DFF40).
  • Sequence similarities

    Contains 1 CIDE-N domain.
  • Post-translational
    modifications

    Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm.
  • Target information above from: UniProt accession O00273 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 13347 Mouse
    • SwissProt: O54786 Mouse
    • Unigene: 41433 Mouse
    • Alternative names

      • A330085O09Rik antibody
      • Caspase activated deoxyribonuclease inhibitor short form antibody
      • DFF 1 antibody
      • DFF 45 antibody
      • DFF alpha antibody
      • DFF-45 antibody
      • DFF1 antibody
      • DFF35 antibody
      • DFF45 antibody
      • DFFA antibody
      • Dffa DNA fragmentation factor, alpha subunit antibody
      • DFFA_HUMAN antibody
      • DNA fragmentation factor 45 kDa subunit antibody
      • DNA Fragmentation Factor Alpha Subunit antibody
      • DNA fragmentation factor subunit alpha antibody
      • DNA fragmentation factor, 45 kD, alpha subunit antibody
      • DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1 antibody
      • DNA fragmentation factor, 45kDa, alpha polypeptide antibody
      • DNA fragmentation factor, alpha subunit antibody
      • DNAation factor 45 kDa subunit antibody
      • H13 antibody
      • ICAD antibody
      • ICAD L antibody
      • ICAD S antibody
      • Inhibitor of CAD antibody
      • Inhibitor of Caspase Activated DNase antibody
      • MGC143066 antibody
      • OTTHUMP00000001903 antibody
      • OTTHUMP00000001904 antibody
      • RP23 121D17.3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAD antibody (ab2040)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAD antibody (ab2040)

      Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse kidney tissue labeling ICAD with Anti-ICAD antibody (ab2040) at 5µg/ml.

    • Western blot - Anti-ICAD antibody (ab2040)
      Western blot - Anti-ICAD antibody (ab2040)

      Western blot analysis of ICAD in murine lung (L), brain (B), liver (L), and kidney tissue lysate with anti-ICAD (CT) at 1/1000 dilution.

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab2040? Please let us know so that we can cite the reference in this datasheet.

    ab2040 has been referenced in 1 publication.

    • Meram AT  et al. Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae. Anticancer Res 38:3843-3852 (2018). PubMed: 29970504

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