Anti-ICAD antibody (ab2040)

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Overview

  • Product name
    Anti-ICAD antibody
    See all ICAD primary antibodies
  • Description
    Rabbit polyclonal to ICAD
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-FrFl, WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide, corresponding to amino acids 312-331 of Mouse ICAD (CT).

  • Positive control
    • Mouse lung tissue lysate.
  • General notes
    Stable for one year.

Properties

Applications

Our Abpromise guarantee covers the use of ab2040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-FrFl Use a concentration of 5 µg/ml.
WB 1/500 - 1/2000. Detects a band of approximately 45 kDa (predicted molecular weight: 45 kDa).

Target

  • Function
    Inhibitor of the caspase-activated DNase (DFF40).
  • Sequence similarities
    Contains 1 CIDE-N domain.
  • Post-translational
    modifications
    Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
    • Alternative names
      • A330085O09Rik antibody
      • Caspase activated deoxyribonuclease inhibitor short form antibody
      • DFF 1 antibody
      • DFF 45 antibody
      • DFF alpha antibody
      • DFF-45 antibody
      • DFF1 antibody
      • DFF35 antibody
      • DFF45 antibody
      • DFFA antibody
      • Dffa DNA fragmentation factor, alpha subunit antibody
      • DFFA_HUMAN antibody
      • DNA fragmentation factor 45 kDa subunit antibody
      • DNA Fragmentation Factor Alpha Subunit antibody
      • DNA fragmentation factor subunit alpha antibody
      • DNA fragmentation factor, 45 kD, alpha subunit antibody
      • DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1 antibody
      • DNA fragmentation factor, 45kDa, alpha polypeptide antibody
      • DNA fragmentation factor, alpha subunit antibody
      • DNAation factor 45 kDa subunit antibody
      • H13 antibody
      • ICAD antibody
      • ICAD L antibody
      • ICAD S antibody
      • Inhibitor of CAD antibody
      • Inhibitor of Caspase Activated DNase antibody
      • MGC143066 antibody
      • OTTHUMP00000001903 antibody
      • OTTHUMP00000001904 antibody
      • RP23 121D17.3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAD antibody (ab2040)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICAD antibody (ab2040)
      Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse kidney tissue labeling ICAD with Anti-ICAD antibody (ab2040) at 5μg/ml.
    • Western blot - Anti-ICAD antibody (ab2040)
      Western blot - Anti-ICAD antibody (ab2040)

      Western blot analysis of ICAD in murine lung (L), brain (B), liver (L), and kidney tissue lysate with anti-ICAD (CT) at 1/1000 dilution.

    References

    This product has been referenced in:
    • Meram AT  et al. Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae. Anticancer Res 38:3843-3852 (2018). Read more (PubMed: 29970504) »
    See 1 Publication for this product

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