Overview

  • Product name

    Icariin, cGMP specific PDE5 inhibitor
  • Description

    Selective cGMP specific PDE5 inhibitor
  • Biological description

    Selective cGMP specific PDE5 inhibitor (IC50 = 0.4 and 74 μM for PDE5 and PDE4 respectively). Shows anti-inflammatory and antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    489-32-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
  • Molecular weight

    676.66
  • Molecular formula

    C33H40O15
  • PubChem identifier

    5318997
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhou J  et al. Icariin and its derivative, ICT, exert anti-inflammatory, anti-tumor effects, and modulate myeloid derived suppressive cells (MDSCs) functions. Int Immunopharmacol 11:890-8 (2011). Read more (PubMed: 21244860) »
  • Cai WJ  et al. Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One 6:e28835 (2011). Read more (PubMed: 22216122) »
  • Xin ZC  et al. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl 5:15-8 (2003). Read more (PubMed: 12646997) »

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