Key features and details
- Highly selective β2 adrenoceptor antagonist
- CAS Number: 72795-01-8
- Purity: > 99%
- Soluble in water to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameICI 118551 hydrochloride, beta2 adrenoceptor antagonist
DescriptionHighly selective β2 adrenoceptor antagonist
Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone in vivo.
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM and in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120808 has been referenced in 4 publications.
- Lan J et al. ß-Adrenoceptors regulate matrix metalloproteinase expression in human urothelial cells under hydrostatic pressure. Neurourol Urodyn 39:1292-1303 (2020). PubMed: 32330364
- Yu H et al. MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife 8:N/A (2019). PubMed: 31500698
- Lai J et al. ß-Adrenoceptor signaling regulates proliferation and contraction of human bladder smooth muscle cells under pathological hydrostatic pressure. J Cell Biochem 120:17872-17886 (2019). PubMed: 31161623
- McMacken G et al. The beta-adrenergic agonist salbutamol modulates neuromuscular junction formation in zebrafish models of human myasthenic syndromes. Hum Mol Genet 27:1556-1564 (2018). PubMed: 29462491