Overview

  • Product name

    ICI 118551 hydrochloride, beta2 adrenoceptor antagonist
  • Description

    Highly selective β2 adrenoceptor antagonist
  • Biological description

    Highly selective β2 adrenoceptor antagonist (Ki values are 1.2, 120 and 257 nM at β2, β1 and β3 receptors, respectively). Blood-brain barrier permeable. Decreases vascular tone in vivo.
  • Purity

    > 99%
  • CAS Number

    72795-01-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R*,3R*)-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol
  • Molecular weight

    313.87
  • Molecular formula

    C17H27NO2.HCl
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wenzel D  et al. beta(2)-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a G(i/o) protein/nitric oxide-coupled pathway. Hypertension 54:157-63 (2009). Read more (PubMed: 19470879) »
  • Ahmad S  et al. Characterization of beta adrenoceptors on cultured endothelial cells by radioligand binding. Life Sci 47:2365-70 (1990). Read more (PubMed: 1979829) »
  • Bilski AJ  et al. The pharmacology of a beta 2-selective adrenoceptor antagonist (ICI 118,551). J Cardiovasc Pharmacol 5:430-7 (0). Read more (PubMed: 6191142) »
See 1 Publication for this product

Customer reviews and Q&As

Question
Answer

Thank you for contacting Abcam.

I have talked to our Biochemical’s team and unfortunately since we do not biologically test any of our compounds the only information we can provide, would be that found in the literature. There is also very little published data on the long term stability of these compounds.

Sorry I cannot be of any more help.

Please let me know if you have any further questions.

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