Key features and details
- TRPM8 agonist. Super-cooling agent.
- CAS Number: 36945-98-9
- Purity: > 97%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameIcilin, TRPM8 agonist
DescriptionTRPM8 agonist. Super-cooling agent.
Biological descriptionTRPM8 agonist (EC50 values are 0.4 and 7 μM in the presence and absence of Ca2+ respectively). Super-cooling agent. Weakly activates TRPA1. Inhibits TRPV3 (IC50 values are 0.5 and 7 μM in the presence and absence of Ca2+ respectively). Produces wet-dog shakes in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141524 has not yet been referenced specifically in any publications.