Overview

  • Product name

    Anti-ICOS Ligand/ICOSL antibody
    See all ICOS Ligand/ICOSL primary antibodies
  • Description

    Goat polyclonal to ICOS Ligand/ICOSL
  • Host species

    Goat
  • Specificity

    ab212020 is expected to recognize all reported isoforms (NP_056074.1; NP_001269979.1; NP_001269980.1; NP_001269981.1).
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ICOS Ligand/ICOSL aa 230-243 (internal sequence) (Cysteine residue).
    Sequence:

    SQTGNDIGERDKIT


    Database link: O75144

  • Positive control

    • Human lymph node cell lysate.
  • General notes

     This product was previously labelled as ICOS Ligand

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab212020 was purified from goat serum by ammonium sulfate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab212020 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

Target

  • Function

    Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
  • Tissue specificity

    Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
  • Sequence similarities

    Belongs to the immunoglobulin superfamily. BTN/MOG family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • B7 H2 antibody
    • B7 homolog 2 antibody
    • B7 homologue 2 antibody
    • B7 like protein Gl50 antibody
    • B7 related protein 1 antibody
    • B7-H2 antibody
    • B7-like protein Gl50 antibody
    • B7-related protein 1 antibody
    • B7H2 antibody
    • B7RP 1 antibody
    • B7RP-1 antibody
    • B7RP1 antibody
    • CD 275 antibody
    • CD275 antibody
    • CD275 antigen antibody
    • GL 50 antibody
    • GL50 antibody
    • ICOS L antibody
    • ICOS LG antibody
    • ICOS ligand antibody
    • ICOSL antibody
    • ICOSL_HUMAN antibody
    • Icoslg antibody
    • Inducible T cell co stimulator ligand antibody
    • KIAA0653 antibody
    • LICOS antibody
    • Transmembrane protein B7 H2 ICOS ligand antibody
    see all

Images

  • Anti-ICOS Ligand/ICOSL antibody (ab212020) at 1 µg/ml + Human lymph node cell lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 33 kDa



    Primary incubation was 1 hour.

References

ab212020 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab212020.
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