Overview

  • Product name

    IDE 1, endoderm formation inducer
  • Description

    Potent cell-permeable definitive endoderm formation inducer
  • Biological description

    Potent cell-permeable definitive endoderm formation inducer (EC50 = 125 nM, ESC) similar to IDE 2 (ab145223). Induces Sox17 expression. Activates TGF-β signaling and downstream Smad2 phosphorylation. Upregulates Nodal expression. Induces gut tube formation in vivo.
  • Purity

    > 99%
  • CAS Number

    1160927-48-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-[2-(2-Carboxybenzylidene)hydrazinyl]-7-oxoheptanoic acid
  • Molecular weight

    306.30
  • Molecular formula

    C15H18N2O5
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM and in ethanol to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    OC(=O)c1ccccc1/C=N/NC(=O)CCCCCC(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Tahamtani Y  et al. Stauprimide Priming of Human Embryonic Stem Cells toward Definitive Endoderm. Cell J 16:63-72 (2014). Read more (PubMed: 24518969) »
  • Tahamtani Y  et al. Treatment of human embryonic stem cells with different combinations of priming and inducing factors toward definitive endoderm. Stem Cells Dev 22:1419-32 (2013). Read more (PubMed: 23249309) »
  • Filby CE  et al. Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res Ther 2:16 (2011). Read more (PubMed: 21463501) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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