Overview

  • Product name

    IDE 2, endoderm formation inducer
  • Description

    Cell-permeable definitive endoderm formation inducer
  • Biological description

    Cell-permeable definitive endoderm formation inducer (EC50 = 223 nM, induction of Sox17 expression in ESCs) similar to IDE 1 (ab145222). Activates TGF-β signaling and downstream Smad2 phosphorylation. Upregulates Nodal expression. Induces gut tube formation in vivo.
  • Purity

    > 98%
  • CAS Number

    1136466-93-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tahamtani Y  et al. Stauprimide Priming of Human Embryonic Stem Cells toward Definitive Endoderm. Cell J 16:63-72 (2014). Read more (PubMed: 24518969) »
  • Tahamtani Y  et al. Treatment of human embryonic stem cells with different combinations of priming and inducing factors toward definitive endoderm. Stem Cells Dev 22:1419-32 (2013). Read more (PubMed: 23249309) »
  • Filby CE  et al. Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res Ther 2:16 (2011). Read more (PubMed: 21463501) »

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