Product nameAnti-IDH3B antibody
See all IDH3B primary antibodies
DescriptionGoat polyclonal to IDH3B
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Predicted to work with: Rat, Cow, Dog, Human, Pig
- Mouse fetal kidney lysate, Mouse fetal skeletal muscle lysate, NIH3T3 cell lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Our Abpromise guarantee covers the use of ab121016 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 42 kDa.|
Involvement in diseaseDefects in IDH3B are the cause of retinitis pigmentosa type 46 (RP46) [MIM:612572]. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence similaritiesBelongs to the isocitrate and isopropylmalate dehydrogenases family.
- Information by UniProt
- FLJ11043 antibody
- H-IDHB antibody
- Idh3B antibody
Anti-IDH3B antibody (ab121016) at 0.03 µg/ml + Mouse fetal kidney lysate at 35 µg
Predicted band size: 42 kDa
Observed band size: 40 kDa why is the actual band size different from the predicted?
This product has been referenced in:
- Findlay AS et al. Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function. Dis Model Mech 11:N/A (2018). Read more (PubMed: 30478029) »
- Abdel Malik R et al. AMP-Activated Protein Kinase a2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1a and a Network of Proteins Affecting Metabolism and Apoptosis. Circ Res 120:99-109 (2017). WB ; Mouse . Read more (PubMed: 27777247) »