Overview

  • Product name

  • Description

    Rabbit polyclonal to IDO-2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human IDO-2 aa 290-340 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q6ZQW0

  • Positive control

    • Rat brain tissue.
  • General notes

    Protein previously labeled as INDOL1.

Properties

Applications

Our Abpromise guarantee covers the use of ab214214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.
  • Tissue specificity

    Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon.
  • Pathway

    Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
  • Sequence similarities

    Belongs to the indoleamine 2,3-dioxygenase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3-dioxygenase 2 antibody
    • 3-dioxygenase-like protein 1 antibody
    • EC 1.13.11. antibody
    • I23O2_HUMAN antibody
    • IDO 2 antibody
    • IDO-2 antibody
    • Ido2 antibody
    • INDOL 1 antibody
    • Indoleamine 2 antibody
    • Indoleamine 2,3 dioxygenase 2 antibody
    • Indoleamine 2,3 dioxygenase like 1 protein antibody
    • Indoleamine 2,3 dioxygenase like protein 1 antibody
    • Indoleamine pyrrole 2,3 dioxygenase like 1 antibody
    • Indoleamine pyrrole 2,3 dioxygenase like protein 1 antibody
    • Indoleamine-pyrrole 2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling IDO-2 with ab214214 at 1/500 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

This product has been referenced in:

  • Yamamoto Y  et al. Lipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling. Sci Rep 8:15917 (2018). Read more (PubMed: 30374077) »
See 1 Publication for this product

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