Overview

  • Product name
    Idoxuridine, Antiviral thymidine analog
  • Description
    Antiviral thymidine analog Radiosensitizer. Anticancer
  • Alternative names
    • (+)-5-Iodo-2'-deoxyuridine
    • IdU
  • Biological description

    Selective cytotoxic cell-permeable anti-herpesvirus agent (IC50 = 4.3 μM). Radiosensitizing. Incorporates into DNA increases susceptibility of cancer cell to radiation damage. Active in vivo.

  • Purity
    > 98%
  • CAS Number
    54-42-2
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
  • Molecular weight
    354.10
  • Molecular formula
    C9H11IN2O5
  • PubChem identifier
    5905
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Chang WY  et al. Evaluation of (131/123)I-5-iodo-2'-deoxycytidine as a novel proliferation probe in a tumor mouse model. Appl Radiat Isot 77:166-73 (2013). Read more (PubMed: 23602704) »
  • Alcolea Palafox M Molecular structure differences between the antiviral Nucleoside Analogue 5-iodo-2'-deoxyuridine and the natural nucleoside 2'-deoxythymidine using MP2 and DFT methods: conformational analysis, crystal simulations, DNA pairs and possible behaviour. J Biomol Struct Dyn : (2013). Read more (PubMed: 23731482) »
  • Maggs DJ & Clarke HE In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res 65:399-403 (2004). Read more (PubMed: 15077679) »
  • Otto SE Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs 21:335-7 (0). Read more (PubMed: 10392098) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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