Overview

  • Product name

    Anti-IDUA antibody - C-terminal
    See all IDUA primary antibodies
  • Description

    Rabbit polyclonal to IDUA - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Horse, Guinea pig, Cow, Cat, Dog
  • Immunogen

    Synthetic peptide within Human IDUA aa 509-558 (C terminal). The exact sequence is proprietary.
    Sequence:

    DPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALP


    Database link: P35475

  • Positive control

    • ACHN whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab178808 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa.

Target

  • Relevance

    IDUA is an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Defects in IDUA are the cause of mucopolysaccharidosis type 1H (MPS1H) also known as Hurler syndrome, mucopolysaccharidosis type 1H/S (MPS1H/S) also known as Hurler-Scheie syndrome and mucopolysaccharidosis type 1S (MPS1S) also known as Scheie syndrome. MPS1S is a mild form whilst MPS1H is a severe form of this rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate.
  • Cellular localization

    Lysosome
  • Database links

  • Alternative names

    • Alpha L iduronidase antibody
    • IDA antibody
    • Iduronidase alpha L antibody
    • MPS1 antibody

Images

  • Anti-IDUA antibody - C-terminal (ab178808) at 1 µg/ml + ACHN whole cell lysate at 10 µg

    Predicted band size: 73 kDa

References

ab178808 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab178808.
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