Key features and details
- Selective GluR2 lacking AMPA receptor blocker. Open channel blocker.
- CAS Number: 121034-89-7
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameIEM-1460, GluR2 lacking AMPA receptor blocker
DescriptionSelective GluR2 lacking AMPA receptor blocker. Open channel blocker.
Selective, Ca2+ permeable GluR2-lacking AMPA receptor blocker (IC50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). Blocks NMDA receptor-mediated currents. Shows anticonvulsant effects in vivo.
Also available in simple stock solutions (ab146737) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical nameN,N,N-Trimethyl-5-[(tricyclo[18.104.22.168,7]dec-1-ylmethyl)amino]-1-pentanaminium bromide hydrobromide
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141507 has been referenced in 3 publications.
- Livingstone RW et al. Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors. Front Mol Neurosci 14:660208 (2021). PubMed: 33867938
- Li X et al. A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2. Cell Rep 34:108741 (2021). PubMed: 33596426
- Glasgow SD et al. Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus. Cell Rep 25:168-182.e6 (2018). PubMed: 30282026