Overview

  • Product name

  • Description

    Rabbit polyclonal to IFITM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, IHC-Fr, IHC-Gmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to a sequence at the N terminus of Human IFITM1, identical to the related Rat and Mouse sequence.

  • Positive control

    • Human intestine cancer sections

Properties

Applications

Our Abpromise guarantee covers the use of ab106265 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 14 kDa.
IHC-P Use a concentration of 0.5 - 1 µg/ml. Boiling the sections is required.
IHC-Fr Use at an assay dependent concentration.
IHC-G Use at an assay dependent concentration. PubMed: 22446628

Target

  • Function

    IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activition or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
  • Sequence similarities

    Belongs to the CD225 family.
  • Post-translational
    modifications

    Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 9-27 antibody
    • CD 225 antibody
    • CD 225 antigen antibody
    • CD225 antibody
    • CD225 antigen antibody
    • Dispanin subfamily A member 2a antibody
    • DSPA2a antibody
    • IFI 17 antibody
    • IFI17 antibody
    • IFITM1 antibody
    • IFM1_HUMAN antibody
    • Interferon induced protein 17 antibody
    • interferon induced transmembrane protein 1 (9-27) antibody
    • Interferon induced transmembrane protein 1 antibody
    • Interferon inducible protein 9-27 antibody
    • Interferon-induced protein 17 antibody
    • Interferon-induced transmembrane protein 1 antibody
    • Interferon-inducible protein 9-27 antibody
    • Leu 13 antibody
    • Leu 13 antigen antibody
    • Leu-13 antigen antibody
    • LEU13 antibody
    see all

Images

  • Staining of IFITM1 in a formalin fixed, paraffin embedded section of Human intestine cancer using ab106265 at a concentration of 1 µg/ml.

References

This product has been referenced in:

See 1 Publication for this product

Customer reviews and Q&As

Application
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample
Mouse Tissue sections (cornea)
Antigen retrieval step
Heat mediated - Buffer/Enzyme Used: Antigen Unmasking solution Citrate-Based (Vector)
Permeabilization
Yes - 0.2%Tween20
Specification
cornea
Blocking step
gelatin as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 0.2% · Temperature: RT°C
Fixative
Formaldehyde

Abcam user community

Verified customer

Submitted May 16 2019

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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