Recombinant
RabMAb

Anti-IFN gamma Receptor beta / AF-1 antibody [EPR8813] (ab171081)

Overview

  • Product name
    Anti-IFN gamma Receptor beta / AF-1 antibody [EPR8813]
    See all IFN gamma Receptor beta / AF-1 primary antibodies
  • Description
    Rabbit monoclonal [EPR8813] to IFN gamma Receptor beta / AF-1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human IFN gamma Receptor beta/ AF-1 aa 300 to the C-terminus (Cysteine residue). The exact sequence is proprietary.
    Database link: P38484

  • Positive control
    • Fetal heart, Human skeletal muscle and fetal thymus lysates.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab171081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 38 kDa.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function
      Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
    • Involvement in disease
      Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
    • Sequence similarities
      Belongs to the type II cytokine receptor family.
      Contains 2 fibronectin type-III domains.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AF 1 antibody
      • AF-1 antibody
      • AF1 antibody
      • IFGR 2 antibody
      • IFGR2 antibody
      • IFN gamma Receptor beta antibody
      • IFN-gamma receptor 2 antibody
      • IFN-gamma-R2 antibody
      • IFNGR 2 antibody
      • IFNGR2 antibody
      • IFNGT 1 antibody
      • IFNGT1 antibody
      • IMD28 antibody
      • INGR2_HUMAN antibody
      • Interferon gamma receptor 2 (interferon gamma transducer 1) antibody
      • Interferon gamma receptor 2 antibody
      • Interferon gamma receptor accessory factor 1 antibody
      • Interferon gamma receptor beta chain antibody
      • Interferon gamma receptor chain 2 antibody
      • Interferon gamma transducer 1 antibody
      see all

    Images

    • All lanes : Anti-IFN gamma Receptor beta / AF-1 antibody [EPR8813] (ab171081) at 1/1000 dilution

      Lane 1 : Fetal heart tissue lysate
      Lane 2 : Human skeletal muscle tissue lysate
      Lane 3 : Fetal thymus tissue lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 38 kDa

    References

    ab171081 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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