Key features and details
- Rabbit polyclonal to IFNAR2 - N-terminal
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-IFNAR2 antibody - N-terminal
See all IFNAR2 primary antibodies
DescriptionRabbit polyclonal to IFNAR2 - N-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
- AD293 cell extract.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
PBS without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab190664 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
Our Abpromise guarantee covers the use of ab190664 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 57 kDa.|
FunctionAssociates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.
Tissue specificityIsoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Sequence similaritiesBelongs to the type II cytokine receptor family.
modificationsPhosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Cellular localizationSecreted and Membrane.
- Information by UniProt
- Human interferon alpha/beta receptor antibody
- IFN alpha REC antibody
- IFN R antibody
ab190664 has not yet been referenced specifically in any publications.