Anti-IgA antibody [KT13] (ab106706)
Key features and details
- Mouse monoclonal [KT13] to IgA
- Suitable for: WB, ELISA
- Reacts with: Human
- Isotype: IgG2a
Overview
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Product name
Anti-IgA antibody [KT13]
See all IgA primary antibodies -
Description
Mouse monoclonal [KT13] to IgA -
Host species
Mouse -
Specificity
ab106706 is Fc specific and reacts with IgA1 and IgA2, but does not cross-react with Human IgG and anti-NP IgG1, IgG2, IgG3, IgG4, IgE and IgM. -
Tested applications
Suitable for: WB, ELISAmore details -
Species reactivity
Reacts with: Human -
Immunogen
Fusion protein corresponding to Human IgA.
Database link: P01876 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
KT13 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106706 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/20000. Predicted molecular weight: 83 kDa.
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ELISA |
Use a concentration of 1 µg/ml.
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Notes |
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WB
1/1000 - 1/20000. Predicted molecular weight: 83 kDa. |
ELISA
Use a concentration of 1 µg/ml. |
Target
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Relevance
Human IgA (immunoglobulin A) is a glycosylated protein of 160 kDa and is produced as a monomer or as a J chain linked dimer. Monomeric IgA constitutes 5-15 % of the serum immunoglobulins whereas dimeric IgA is localized to mucosa surfaces such as saliva, gastrointestinal secretion, bronchial fluids and milk. Mucosal IgA plays a major role in host defence by neutralising infectious agents at mucosal surfaces. The production is usually local and antigen specific IgA producing B cells can be found in regions under the lamina propria where they mature into dimeric IgA producing plasma cells. IgA deficiency is the most common immunodeficiency that may affect both serum and mucosal produced IgA. OR: The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 3494 Human
- Entrez Gene: 5284 Human
- Omim: 146900 Human
- Omim: 147000 Human
- Omim: 173880 Human
- SwissProt: P01876 Human
- SwissProt: P01877 Human
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Alternative names
- Hepatocellular carcinoma-associated protein TB6 antibody
- Ig alpha 1 chain C region antibody
- Ig alpha 2 chain C region antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab106706 has not yet been referenced specifically in any publications.