Overview

  • Product name
    Anti-IGF1 antibody [7973]
    See all IGF1 primary antibodies
  • Description
    Mouse monoclonal [7973] to IGF1
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-P, IHC-Fr, RIAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Full length protein corresponding to Human IGF1. conjugated to carrier protein
    Database link: P05019

Properties

Applications

Our Abpromise guarantee covers the use of ab176523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 1 µg/ml.
IHC-Fr Use at an assay dependent concentration.
RIA Use at an assay dependent concentration.

Target

  • Function
    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
  • Involvement in disease
    Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
  • Sequence similarities
    Belongs to the insulin family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Form
    There are 2 isoforms produced by alternative splicing. Isoform 1 also known as: IGF-IB; Isoform 2 also known as: IGF-IA.
  • Alternative names
    • IBP1 antibody
    • IGF I antibody
    • IGF IA antibody
    • IGF IB antibody
    • IGF-I antibody
    • Igf1 antibody
    • IGF1_HUMAN antibody
    • IGF1A antibody
    • IGFI antibody
    • IGFIA antibody
    • Insulin like growth factor 1 (somatomedin C) antibody
    • Insulin like growth factor 1 antibody
    • Insulin like growth factor IA antibody
    • Insulin like growth factor IB antibody
    • Insulin-like growth factor I antibody
    • Mechano growth factor antibody
    • MGF antibody
    • OTTHUMP00000195080 antibody
    • OTTHUMP00000195081 antibody
    • OTTHUMP00000195082 antibody
    • OTTHUMP00000195083 antibody
    • OTTHUMP00000195084 antibody
    • Somatomedia C antibody
    • Somatomedin C antibody
    • Somatomedin-C antibody
    see all

Images

  • Immunohistochemical analysis of Formalin Fixed Parafin-embedded normal Human kidney tissue labeling IGF1 with ab176523 at 1ug/ml.

  • Immunohistochemical analysis of Formalin Fixed Parafin-embedded normal Human kidney tissue labeling IGF1 with ab176523 at 1ug/ml.

References

This product has been referenced in:
  • Ogundele OM  et al. A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIa Phosphorylation. Front Neuroanat 12:35 (2018). Read more (PubMed: 29867375) »
  • Ogundele OM  et al. Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIa expression in neural changes associated with a prolonged exposure therapy. Neuroscience 353:147-165 (2017). WB ; Rat . Read more (PubMed: 28438613) »
See all 3 Publications for this product

Customer reviews and Q&As

Answer

A BLAST alignment shows only 58% homology between IGF1 and IGF2. Since the full length IGF1 protein was used to generate this antibody, it is unlikely to cross react with IGF2. Typically, we find that greater than 85% homology is needed for cross reactivity. I hope this helps!

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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