Overview

  • Product name

  • Description

    Goat polyclonal to IGF2
  • Host species

    Goat
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:

    ETYCATPAKSERD

    , corresponding to internal sequence amino acids 81-93 of Human IGF2 (NP_000603.1; NP_001121070.1).

Properties

Applications

Our Abpromise guarantee covers the use of ab123812 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
    Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
  • Involvement in disease

    Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
  • Sequence similarities

    Belongs to the insulin family.
  • Post-translational
    modifications

    O-glycosylated with a core 1 or possibly core 8 glycan.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • C11orf43 antibody
    • IGF 2 antibody
    • IGF II antibody
    • IGF-II antibody
    • IGF2 antibody
    • IGF2_HUMAN antibody
    • IGFII antibody
    • INSIGF antibody
    • insulin like growth factor 2 (somatomedin A) antibody
    • Insulin like Growth Factor 2 antibody
    • Insulin like growth factor II antibody
    • Insulin like growth factor II precursor antibody
    • Insulin like growth factor type 2 antibody
    • pp9974 antibody
    • Preptin antibody
    • putative insulin like growth factor II associated protein antibody
    • Somatomedin A antibody
    • Somatomedin-A antibody
    see all

Images

  • ab123812 (5µg/ml) shows staining of IGF2 in paraffin embedded Human Cerebellum following steamed antigen retrieval with citrate buffer pH 6 and AP-staining. This shows axonal staining.

References

This product has been referenced in:

  • Kero D  et al. Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ - an immunohistochemical study. Organogenesis 12:152-167 (2016). Read more (PubMed: 27326759) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer

That particular antibody is not available for the testing discount program. That is the case for all the Fast Track antibodies.

However, we always encourage customer to submit reviews, regardless of whether the testing program is available, for instance for applications or species that are already covered byu our guarantee.

Reviews of Fast Track antibodies fall into a special category. Reviews of these are awarded more credits than reviews of other antibodies that are more fully characterized. The difference is that we require an image for these reviews. A description of the AbReview policy can be found by clicking on the "terms and conditions" link at the top of the datasheet:

Click here (or use the following: https://www.abcam.com/index.html?datasheet=123812).

And I have copied it here:

Feedback reward
We would greatly appreciate your feedback on these antibodies, whether positive or negative. We will award 950 bonus Abpoints to the first researcher who sends us positive feedback (including an image and details of materials and methods). Conclusive negative feedback that leads us to withdraw the antibody will also be rewarded with 950 bonus Abpoints. Other useful positive and negative feedback will be rewarded with the standard Abpoints for submitting an Abreview (please refer to Abreviews terms and conditions for more detailed information). All awards are subject to approval by Abcam scientists and provision of suitable data. Please submit feedback to fast-track@abcam.com

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Question
Answer

For that antibody, ab123812, the peptide is not commercially available. Please note that this is one of our Fast Track antibodies, meaning it has not been as thoroughly characterized as other antibodies, and that is why the price is lower than the prices of other, more fully characterized antibodies. It was added to the catalogue earlier this month..

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