The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Involvement in disease
Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
Belongs to the insulin family.
O-glycosylated with a core 1 or possibly core 8 glycan.
Immuhistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling IGF2 with ab170304 at 1/50 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.
Flow Cytometry - Anti-IGF2 antibody (ab170304)
Flow cytometric analysis of HeLa cells labeling IGF2 with ab170304 at 1/10 dilution (right histogram) compared to a negative control cell (left histogram).