Anti-IGF2 antibody (ab9574)

Rabbit polyclonal IGF2 antibody. Validated in WB, ELISA, IHC, Neut, ICC/IF and tested in Rat, Cow, Human. Cited in 56 publication(s). Independently reviewed in 19 review(s).

Publishing research using ab9574? Please let us know so that we can cite the reference in this datasheet.

ab9574 has been referenced in 66 publications.

  • Hausken J  et al. A patient with solid gynecologic cancer causing lactic acidosis, severe hypercalcemia, and hypoglycemia. Clin Case Rep 7:64-70 (2019). PubMed: 30656010
  • van de Looij Y  et al. Nutritional Intervention for Developmental Brain Damage: Effects of Lactoferrin Supplementation in Hypocaloric Induced Intrauterine Growth Restriction Rat Pups. Front Endocrinol (Lausanne) 10:46 (2019). PubMed: 30800096
  • Zhen N  et al. CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis. Theranostics 9:900-919 (2019). PubMed: 30809316
  • Roychowdhury A  et al. IGF2 is Deregulated During the Development of Uterine Cervical Carcinoma in Indian Patients. Biochem Genet N/A:N/A (2019). PubMed: 30949792
  • Lu L  et al. miR-491-5p functions as a tumor suppressor by targeting IGF2 in colorectal cancer. Cancer Manag Res 11:1805-1816 (2019). PubMed: 30863186
  • Heras-Bautista CO  et al. Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts. Acta Biomater 89:180-192 (2019). PubMed: 30862552
  • Watanabe K  et al. Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations. Hepatol Commun 3:697-715 (2019). PubMed: 31061957
  • Suzuki T  et al. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development 146:N/A (2019). PubMed: 30733279
  • Serna VA  et al. Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo. Endocr Relat Cancer 25:747-759 (2018). PubMed: 29700012
  • Liu X  et al. DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/ß-catenin signal pathways. Cell Death Dis 9:1037 (2018). PubMed: 30305607
  • Van Arsdale AR  et al. Insulin-like growth factor 2: a poor prognostic biomarker linked to racial disparity in women with uterine carcinosarcoma. Cancer Med 7:616-625 (2018). IHC-P ; Human . PubMed: 29455465
  • Ireland L  et al. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene 37:2022-2036 (2018). IHC-P . PubMed: 29367764
  • Shi L  et al. DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1. J Genet Genomics 45:205-214 (2018). PubMed: 29735329
  • Afshar S  et al. MiR-185 enhances radiosensitivity of colorectal cancer cells by targeting IGF1R and IGF2. Biomed Pharmacother 106:763-769 (2018). PubMed: 29990869
  • Hosen MR  et al. Airn Regulates Igf2bp2 Translation in Cardiomyocytes. Circ Res 122:1347-1353 (2018). PubMed: 29483092
  • Steffensen LL  et al. Transcripts Encoding the Androgen Receptor and IGF-Related Molecules Are Differently Expressed in Human Granulosa Cells From Primordial and Primary Follicles. Front Cell Dev Biol 6:85 (2018). PubMed: 30148131
  • Liu Y  et al. Folic Acid Reduced Triglycerides Deposition in Primary Chicken Hepatocytes. J Agric Food Chem N/A:N/A (2018). PubMed: 30484310
  • McKay TB  et al. Differential Effects of Hormones on Cellular Metabolism in Keratoconus In Vitro. Sci Rep 7:42896 (2017). PubMed: 28211546
  • Shi-Peng G  et al. TMED2 promotes epithelial ovarian cancer growth. Oncotarget 8:94151-94165 (2017). PubMed: 29212217
  • Hamilton N  et al. Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer. Int J Mol Sci 18:N/A (2017). PubMed: 29099049
  • Mussar K  et al. A CCR2+ myeloid cell niche required for pancreatic ß cell growth. JCI Insight 2:N/A (2017). PubMed: 28768911
  • Zhu M  et al. Lnc-mg is a long non-coding RNA that promotes myogenesis. Nat Commun 8:14718 (2017). WB . PubMed: 28281528
  • Allodi I  et al. Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS. Sci Rep 6:25960 (2016). PubMed: 27180807
  • Chen Y  et al. Proteomic analysis of cerebrospinal fluid in amyotrophic lateral sclerosis. Exp Ther Med 11:2095-2106 (2016). PubMed: 27284291
  • Houlihan SL  et al. Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis. Elife 5:N/A (2016). IHC-Fr ; Mouse . PubMed: 27664421
  • Kashyap AS  et al. Antagonists of IGF:Vitronectin Interactions Inhibit IGF-I-Induced Breast Cancer Cell Functions. Mol Cancer Ther 15:1602-13 (2016). PubMed: 27196774
  • de Lint K  et al. Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R. Mol Cancer Ther 15:1545-56 (2016). PubMed: 27196766
  • Steinmetz AB  et al. Insulin-like growth factor 2 rescues aging-related memory loss in rats. Neurobiol Aging 44:9-21 (2016). PubMed: 27318130
  • Uchimura T  et al. Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1ß-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis. J Cell Biochem 116:2858-69 (2015). PubMed: 26015264
  • Chen X  et al. Differential reactivation of fetal/neonatal genes in mouse liver tumors induced in cirrhotic and non-cirrhotic conditions. Cancer Sci 106:972-81 (2015). IHC . PubMed: 26011625
  • Ye X  et al. Insulin Like Growth Factor 2 Expression in the Rat Brain Both in Basal Condition and following Learning Predominantly Derives from the Maternal Allele. PLoS One 10:e0141078 (2015). WB . PubMed: 26495851
  • Thomsen J  et al. PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma. Oncotarget 6:32266-78 (2015). IHC . PubMed: 26336825
  • Podobed P  et al. The day/night proteome in the murine heart. Am J Physiol Regul Integr Comp Physiol 307:R121-37 (2014). PubMed: 24789993
  • Kan SH  et al. Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB. Proc Natl Acad Sci U S A 111:14870-5 (2014). Mouse . PubMed: 25267636
  • Modi H  et al. Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function. J Biol Chem 289:31972-82 (2014). PubMed: 25271169
  • Laggai S  et al. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res 55:1087-97 (2014). PubMed: 24755648
  • Gao W  et al. miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. Oncogene 0:N/A (2014). IHC-P ; Human . PubMed: 24769899
  • Kabaroff L  et al. Development of genetically flexible mouse models of sarcoma using RCAS-TVA mediated gene delivery. PLoS One 9:e94817 (2014). IHC-P ; Mouse, Human . PubMed: 24733554
  • Zhu D  et al. Upregulation of IGF2 expression during vascular calcification. J Mol Endocrinol 52:77-85 (2014). PubMed: 24482492
  • Brouwer-Visser J  et al. Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. PLoS One 9:e100165 (2014). WB, IHC-P ; Mouse . PubMed: 24932685
  • Chun YS  et al. Expression levels of insulin-like growth factors and receptors in hepatocellular carcinoma: a retrospective study. World J Surg Oncol 12:231 (2014). IHC-P ; Human . PubMed: 25052889
  • Pascual-Lucas M  et al. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO Mol Med N/A:N/A (2014). WB ; Mouse, Human . PubMed: 25100745
  • Finotello R  et al. Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity. Vet Comp Oncol N/A:N/A (2014). PubMed: 24428588
  • Fitzgerald JB  et al. MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors. Mol Cancer Ther 13:410-25 (2014). PubMed: 24282274
  • Setoyama T  et al. Bioactive insulin-like growth factors as a possible molecular target for non-islet cell tumor hypoglycemia. Cancer Biol Ther 15:1588-92 (2014). PubMed: 25535894
  • Szarvas T  et al. Prognostic value of tissue and circulating levels of IMP3 in prostate cancer. Int J Cancer 135:1596-604 (2014). PubMed: 24615121
  • Kessler SM  et al. IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling. Am J Physiol Gastrointest Liver Physiol 304:G328-36 (2013). Neutralising ; Human . PubMed: 23257922
  • Venkatraman A  et al. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature 500:345-9 (2013). PubMed: 23863936
  • Pereira SS  et al. The emerging role of the molecular marker p27 in the differential diagnosis of adrenocortical tumors. Endocr Connect 2:137-45 (2013). PubMed: 23925558
  • Li L  et al. Targeted disruption of hotair leads to homeotic transformation and gene derepression. Cell Rep 5:3-12 (2013). ICC/IF ; Mouse . PubMed: 24075995
  • Suh HS  et al. Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation 10:37 (2013). WB, IHC-P . PubMed: 23497056
  • Marquardt JU  et al. Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients. Hepatology 58:1054-64 (2013). WB ; Mouse . PubMed: 23526469
  • Drelon C  et al. Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models. PLoS One 7:e44171 (2012). IHC . PubMed: 22952916
  • Alajez NM  et al. Lin28b promotes head and neck cancer progression via modulation of the insulin-like growth factor survival pathway. Oncotarget 3:1641-52 (2012). IHC ; Human . PubMed: 23482325
  • McCarthy SD  et al. Temporal changes in endometrial gene expression and protein localization of members of the IGF family in cattle: effects of progesterone and pregnancy. Physiol Genomics 44:130-40 (2012). IHC-P ; Cow . PubMed: 22085906
  • Agis-Balboa RC  et al. A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. EMBO J 30:4071-83 (2011). WB, IHC-Fr ; Mouse . PubMed: 21873981
  • Gardner S  et al. TGF-ß inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II. Mol Endocrinol 25:128-37 (2011). WB ; Mouse . PubMed: 21106882
  • Hardouin SN  et al. Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development 138:203-13 (2011). PubMed: 21148188
  • Baumuratova T  et al. Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network. BMC Syst Biol 4:146 (2010). PubMed: 21044309
  • Brachet A  et al. Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier. J Cell Biol 191:383-95 (2010). PubMed: 20956383
  • Huang GS  et al. Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. Clin Cancer Res 16:2999-3010 (2010). IHC-P ; Human . PubMed: 20404007
  • Steigen SE  et al. Expression of insulin-like growth factor 2 in mesenchymal neoplasms. Mod Pathol 22:914-21 (2009). IHC-P ; Human . PubMed: 19407853
  • Li L  et al. Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes. Acta Biochim Biophys Sin (Shanghai) 41:464-71 (2009). PubMed: 19499149
  • Chenau J  et al. The cell line secretome, a suitable tool for investigating proteins released in vivo by tumors: application to the study of p53-modulated proteins secreted in lung cancer cells. J Proteome Res 8:4579-91 (2009). WB ; Human . PubMed: 19639960
  • Vuononvirta R  et al. Perilobar nephrogenic rests are nonobligate molecular genetic precursor lesions of insulin-like growth factor-II-associated Wilms tumors. Clin Cancer Res 14:7635-44 (2008). IHC-P ; Human . PubMed: 19047088
  • Wilson EM  et al. Autocrine growth factor signaling by insulin-like growth factor-II mediates MyoD-stimulated myocyte maturation. J Biol Chem 278:41109-13 (2003). PubMed: 12941952

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