Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab4249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 30 kDa.

Detects 10ng SDS denatured human IGFBP 1.

IP 1/500.

Precipitates >90% of 10ng IGFBP 1. 

Target

  • Function
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
  • Sequence similarities
    Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • Post-translational
    modifications
    Phosphorylated; probably by casein kinase II. Alters the affinity of the protein for IGFs.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • AFBP antibody
    • Alpha pregnancy associated endometrial globulin antibody
    • Amniotic fluid binding protein antibody
    • Binding protein 25 antibody
    • Binding protein 26 antibody
    • Binding protein 28 antibody
    • Growth hormone independent binding protein antibody
    • hIGFBP 1 antibody
    • hIGFBP1 antibody
    • IBP 1 antibody
    • IBP-1 antibody
    • IBP1 antibody
    • IBP1_HUMAN antibody
    • IGF binding protein 1 antibody
    • IGF BP25 antibody
    • IGF-binding protein 1 antibody
    • IGFBP 1 antibody
    • IGFBP-1 antibody
    • IGFBP1 antibody
    • Insulin like growth factor binding protein 1 antibody
    • Insulin-like growth factor-binding protein 1 antibody
    • Placental protein 12 antibody
    • PP 12 antibody
    • PP12 antibody
    see all

References

This product has been referenced in:
  • Zhang Y  et al. Crosstalk between human endometrial stromal cells and decidual NK cells promotes decidualization in vitro by upregulating IL-25. Mol Med Rep 17:2869-2878 (2018). Read more (PubMed: 29257317) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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