Overview

  • Product name

  • Description

    Rabbit polyclonal to IGFBP2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Pig
  • Immunogen

    Recombinant fragment within Human IGFBP2 (internal sequence). The exact sequence is proprietary.
    Database link: P18065

  • Positive control

    • ICC/IF: Huh-7 cells. IHC-P: Human breast carcinoma tissue. WB: SK-N-AS whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab227881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • Sequence similarities

    Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • Domain

    The C-terminus is required for IGF-binding and growth inhibition.
  • Post-translational
    modifications

    O-glycosylated.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • BP 2 antibody
    • BP2 antibody
    • IBP 2 antibody
    • IBP-2 antibody
    • IBP2 antibody
    • IBP2_HUMAN antibody
    • IGF binding protein 2 antibody
    • IGF BP53 antibody
    • IGF-binding protein 2 antibody
    • IGFBP 2 antibody
    • IGFBP-2 antibody
    • IGFBP2 antibody
    • IGFBP53 antibody
    • Insulin like growth factor binding protein 2 36kDa antibody
    • Insulin like growth factor binding protein 2 antibody
    • Insulin like growth factor-binding protein 2 precursor antibody
    • Insulin-like growth factor-binding protein 2 antibody
    see all

Images

  • Anti-IGFBP2 antibody (ab227881) at 1/1000 dilution + SK-N-AS whole cell lysate at 30 µg

    Predicted band size: 35 kDa



    10 % SDS-PAGE gel.

  • Huh-7 cells stained for IGFBP2 (green) using ab227881 at 1/500 dilution in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

    Blue: Hoechst 33342 staining.

  • Paraffin-embedded human breast carcinoma tissue stained for IGFBP2 using ab227881 at 1/500 dilution in immunohistochemical analysis.

References

ab227881 has not yet been referenced specifically in any publications.

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