Anti-IkB beta (phospho S23) antibody (ab75746)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IkB beta (phospho S23) antibody (ab75746)

    Key features and details

    • Rabbit polyclonal to IkB beta (phospho S23)
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-IkB beta (phospho S23) antibody
      See all IKB beta primary antibodies

    • Description

      Rabbit polyclonal to IkB beta (phospho S23)

    • Host species

      Rabbit

    • Specificity

      ab75746 detects endogenous levels of total IkB beta protein.

    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data

    • Immunogen

      Synthetic phosphopeptide derived from human IkB beta around the phosphorylation site of serine 23 (L-G-SP-L-G ).

    • Positive control

      • Human breast carcinoma tissue.

    Properties

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab75746 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    Application Abreviews Notes
    IHC-P
    1/50 - 1/100.
    Notes
    IHC-P
    1/50 - 1/100.

    Target

    • Function

      Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

    • Tissue specificity

      Expressed in all tissues examined.

    • Sequence similarities

      Belongs to the NF-kappa-B inhibitor family.
      Contains 6 ANK repeats.

    • Post-translational
      modifications

      Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

    • Cellular localization

      Cytoplasm. Nucleus.
    • Information by UniProt

    • Database links

      • Alternative names

        • I kappa B beta antibody
        • I-kappa-B-beta antibody
        • IkappaBbeta antibody
        • IKB beta antibody
        • IkB-B antibody
        • IkB-beta antibody
        • IKBB antibody
        • IKBB_HUMAN antibody
        • IkBbeta antibody
        • NF kappa BIB antibody
        • NF-kappa-B inhibitor beta antibody
        • NF-kappa-BIB antibody
        • Nfkbib antibody
        • Thyroid receptor interacting protein 9 antibody
        • Thyroid receptor-interacting protein 9 antibody
        • TR interacting protein 9 antibody
        • TR-interacting protein 9 antibody
        • TRIP-9 antibody
        • TRIP9 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IkB beta (phospho S23) antibody (ab75746)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IkB beta (phospho S23) antibody (ab75746)
        ab75746, at a 1/50 dilution, staining IkB beta in paraffin embedded human breast carcinoma tissue by Immunohistochemistry, in the absence (left image) or presence (right image) of the immunizing phospho peptide.

      References (2)

      Publishing research using ab75746? Please let us know so that we can cite the reference in this datasheet.

      ab75746 has been referenced in 2 publications.

      • Zhou ZX  et al. Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF-?B in animal models of acute pharyngitis. Mol Med Rep 17:1269-1274 (2018). PubMed: 29115472
      • Kane J  et al. Hematopoietic stem and progenitor cell migration after hypofractionated radiation therapy in a murine model. Int J Radiat Oncol Biol Phys 87:1162-70 (2013). Mouse . PubMed: 24113056

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