Anti-IkB beta (phospho S23) antibody (ab75746)

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Overview

  • Product name

    Anti-IkB beta (phospho S23) antibody
    See all IKB beta primary antibodies

  • Description

    Rabbit polyclonal to IkB beta (phospho S23)

  • Host species

    Rabbit

  • Specificity

    ab75746 detects endogenous levels of total IkB beta protein.

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic phosphopeptide derived from human IkB beta around the phosphorylation site of serine 23 (L-G-SP-L-G ).

  • Positive control

    • Human breast carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab75746 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.

Target

  • Function

    Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

  • Tissue specificity

    Expressed in all tissues examined.

  • Sequence similarities

    Belongs to the NF-kappa-B inhibitor family.
    Contains 6 ANK repeats.

  • Post-translational
    modifications

    Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

  • Cellular localization

    Cytoplasm. Nucleus.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • I kappa B beta antibody
    • I-kappa-B-beta antibody
    • IkappaBbeta antibody
    • IKB beta antibody
    • IkB-B antibody
    • IkB-beta antibody
    • IKBB antibody
    • IKBB_HUMAN antibody
    • IkBbeta antibody
    • NF kappa BIB antibody
    • NF-kappa-B inhibitor beta antibody
    • NF-kappa-BIB antibody
    • Nfkbib antibody
    • Thyroid receptor interacting protein 9 antibody
    • Thyroid receptor-interacting protein 9 antibody
    • TR interacting protein 9 antibody
    • TR-interacting protein 9 antibody
    • TRIP-9 antibody
    • TRIP9 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IkB beta (phospho S23) antibody (ab75746)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IkB beta (phospho S23) antibody (ab75746)
    ab75746, at a 1/50 dilution, staining IkB beta in paraffin embedded human breast carcinoma tissue by Immunohistochemistry, in the absence (left image) or presence (right image) of the immunizing phospho peptide.

References

This product has been referenced in:

  • Zhou ZX  et al. Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF-?B in animal models of acute pharyngitis. Mol Med Rep 17:1269-1274 (2018). Read more (PubMed: 29115472) »
  • Kane J  et al. Hematopoietic stem and progenitor cell migration after hypofractionated radiation therapy in a murine model. Int J Radiat Oncol Biol Phys 87:1162-70 (2013). Mouse . Read more (PubMed: 24113056) »
See all 2 Publications for this product

Publishing research using ab75746? Please let us know so that we can cite the reference in this datasheet.

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