Key features and details
- Rabbit polyclonal to IKB zeta
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-IKB zeta antibody
See all IKB zeta primary antibodies
DescriptionRabbit polyclonal to IKB zeta
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rat, Cow
Recombinant fragment, corresponding to a region within amino acids 303-609 of Human IKB zeta (UniProt Q9BYH8).
- HeLa nuclear lysate.
Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab155142 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 78 kDa.|
FunctionInvolved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
Tissue specificityExpressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart.
Sequence similaritiesContains 7 ANK repeats.
Cellular localizationNucleus. Aggregated in dot-like structures. Colocalizes with NCOR2.
- Information by UniProt
- FLJ30225 antibody
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- I-kappa-B-zeta antibody
ab155142 has been referenced in 1 publication.
- Liu S et al. IL-17A synergistically enhances TLR3-mediated IL-36? production by keratinocytes: A potential role in injury-amplified psoriatic inflammation. Exp Dermatol 28:233-239 (2019). PubMed: 30614571