IKK-16, IkappaB kinase inhibitor (ab216471)
Key features and details
- Potent, selective IκB kinase inhibitor
- CAS Number: 1186195-62-9
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IKK-16, IkappaB kinase inhibitor -
Description
Potent, selective IκB kinase inhibitor -
Alternative names
- IKK Inhibitor VII
- IKK16
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General notes
This product is manufactured by BioVision, an Abcam company and was previously called B1087 IKK16. B1087-25 is the same size as the 25 mg size of ab216471.
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CAS Number
1186195-62-9 -
Chemical structure
Properties
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Chemical name
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride -
Molecular weight
520.09 -
Molecular formula
C28H29N5OS.HCl -
PubChem identifier
56972179 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
SMILES
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl -
Source
Synthetic
Images
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2D chemical structure image of ab216471, IKK-16, IkappaB kinase inhibitor
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Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.
A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments).
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab216471 has been referenced in 3 publications.
- Valionyte E et al. The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner. Cell Death Differ 29:1211-1227 (2022). PubMed: 34862482
- Lanfranco MF et al. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation. Glia 69:1478-1493 (2021). PubMed: 33556209
- Carretta M et al. BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. PLoS One 12:e0189102 (2017). PubMed: 29240787