Overview

  • Product name

    IKK-16, IkappaB kinase inhibitor
  • Description

    Potent, selective IκB kinase inhibitor
  • Alternative names

    • IKK Inhibitor VII
    • IKK16
  • CAS Number

    1186195-62-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride
  • Molecular weight

    520.09
  • Molecular formula

    C28H29N5OS.HCl
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • SMILES

    Cl.O=C(N1CCC(CC1)N2CCCC2)c3ccc(cc3)Nc4nccc(n4)c5cc6ccccc6s5

Images

  • Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.

    A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments).

References

This product has been referenced in:

  • Coldewey SM  et al. Inhibition of I?B kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Model Mech 6:1031-42 (2013). Read more (PubMed: 23649820) »
  • Waelchli R  et al. Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. Bioorg Med Chem Lett 16:108-12 (2006). Read more (PubMed: 16236504) »
See 1 Publication for this product

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