Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab7897 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • I kappa B kinase epsilon
    • I-kappa-B kinase epsilon
    • IkBKE
    • IKK related kinase epsilon
    • IKK-E
    • IKK-epsilon
    • IKK-i
    • IKKE
    • IKKE_HUMAN
    • IKKepsilon
    • IKKI
    • Inducible I kappa B kinase
    • Inducible I kappa-B kinase
    • Inducible IkappaB kinase
    • Inhibitor of kappa light polypeptide gene enhancer in B cells kinase epsilon
    • Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase of, epsilon
    • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
    • KIAA0151
    • MGC125294
    • MGC125295
    • MGC125297
    see all
  • Function
    Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
  • Tissue specificity
    Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated.
    Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.
  • Cellular localization
    Cytoplasm. Nucleus. Nucleus > PML body. Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent.
  • Information by UniProt

References

ab7897 has not yet been referenced specifically in any publications.

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