Anti-IL-1 alpha antibody (ab7632)
Key features and details
- Rabbit polyclonal to IL-1 alpha
- Suitable for: ELISA, IHC-Fr, Neutralising, ICC/IF, IHC-P, Flow Cyt, WB
- Reacts with: Mouse, Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-IL-1 alpha antibody
See all IL-1 alpha primary antibodies -
Description
Rabbit polyclonal to IL-1 alpha -
Host species
Rabbit -
Tested applications
Suitable for: ELISA, IHC-Fr, Neutralising, ICC/IF, IHC-P, Flow Cyt, WBmore details -
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Non human primates
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Immunogen
Recombinant full length protein corresponding to Human IL-1 alpha.
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Positive control
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading... -
Purity
IgG fraction -
Purification notes
whole rabbit serum purified by DEAE fractionation -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab7632 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| IHC-Fr |
Use at an assay dependent concentration.
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| Neutralising |
Use at an assay dependent concentration.
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| ICC/IF | (2) |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration. PubMed: 22190968
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| Flow Cyt | (1) |
Use at an assay dependent concentration.
ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
| WB | (1) |
Use at an assay dependent concentration.
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| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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IHC-Fr
Use at an assay dependent concentration. |
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Neutralising
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. PubMed: 22190968 |
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Flow Cyt
Use at an assay dependent concentration. ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody. |
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WB
Use at an assay dependent concentration. |
Target
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Function
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. -
Sequence similarities
Belongs to the IL-1 family. -
Domain
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. -
Cellular localization
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. - Information by UniProt
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Database links
- Entrez Gene: 3552 Human
- Entrez Gene: 16175 Mouse
- Omim: 147760 Human
- SwissProt: P01583 Human
- SwissProt: P01582 Mouse
- Unigene: 1722 Human
- Unigene: 15534 Mouse
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Alternative names
- BAF antibody
- FAF antibody
- Hematopoietin 1 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (23)
ab7632 has been referenced in 23 publications.
- Collier JJ et al. Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis. Mol Metab 44:101140 (2021). PubMed: 33285301
- Lu X et al. miR-335-5P contributes to human osteoarthritis by targeting HBP1. Exp Ther Med 21:109 (2021). PubMed: 33335572
- Cao H et al. Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-?B axis. Aging (Albany NY) 13:11455-11469 (2021). PubMed: 33839699
- Wang X et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis 12:402 (2021). PubMed: 33854044
- Wang X et al. An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling. Front Pharmacol 12:673818 (2021). PubMed: 34093202