Overview

  • Product name

    Anti-IL-1 alpha antibody [EPR5103(2)]
    See all IL-1 alpha primary antibodies
  • Description

    Rabbit monoclonal [EPR5103(2)] to IL-1 alpha
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human IL-1 alpha aa 200-300. The exact sequence is proprietary.

  • Positive control

    • Human skin tissue lysate; Recombinant Human IL-1 alpha protein.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab134908 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 31 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
    • Sequence similarities

      Belongs to the IL-1 family.
    • Domain

      The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
    • Cellular localization

      Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
    • Information by UniProt
    • Database links

    • Alternative names

      • BAF antibody
      • FAF antibody
      • Hematopoietin 1 antibody
      • Hematopoietin-1 antibody
      • IL 1 alpha antibody
      • IL 1A antibody
      • IL-1 alpha antibody
      • Il-1a antibody
      • IL1 ALPHA antibody
      • IL1 antibody
      • IL1A antibody
      • IL1A_HUMAN antibody
      • IL1F1 antibody
      • Interleukin 1 alpha antibody
      • Interleukin-1 alpha antibody
      • Interleukin1 alpha antibody
      • LAF antibody
      • LEM antibody
      • Preinterleukin 1 alpha antibody
      • Pro interleukin 1 alpha antibody
      see all

    Images

    • Anti-IL-1 alpha antibody [EPR5103(2)] (ab134908) at 1/1000 dilution + Human skin tissue lysate at 10 µg

      Secondary
      HRP-conjugated goat anti-rabbit IgG polyclonal at 1/2000 dilution

      Predicted band size: 31 kDa

    • Anti-IL-1 alpha antibody [EPR5103(2)] (ab134908) at 1/1000 dilution + Recombinant Human IL-1 alpha protein at 0.01 µg

      Secondary
      HRP-conjugated goat anti-rabbit IgG polyclonal at 1/2000 dilution

      Predicted band size: 31 kDa

    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    This product has been referenced in:

    • Singh AK  et al. Critical role of IL-1a in IL-1ß-induced inflammatory responses: cooperation with NF-?Bp65 in transcriptional regulation. FASEB J 33:2526-2536 (2019). Read more (PubMed: 30272996) »
    See 1 Publication for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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