Overview

  • Product name
    Anti-IL-1 Receptor I / IL-1R-1 antibody [D14e3]
    See all IL-1 Receptor I / IL-1R-1 primary antibodies
  • Description
    Rat monoclonal [D14e3] to IL-1 Receptor I / IL-1R-1
  • Host species
    Rat
  • Specificity
    Binds to soluble mouse interleukin-1 receptor type I.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • General notes


    The IL-1 system includes two agonists (IL-1 alpha and IL-1 alpha), converting enzymes, antagonists, two receptors (IL-1 RI and IL-1 RII) and the IL-1 receptor accessory protein. Interleukin-1 signal is transduced through the type I receptor.

    Previously labelled as IL1 Receptor I. 

Properties

Applications

Our Abpromise guarantee covers the use of ab8157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration.

Target

  • Function
    Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
  • Sequence similarities
    Belongs to the interleukin-1 receptor family.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 TIR domain.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen CD121a antibody
    • CD121 antigen-like family member A antibody
    • CD121a antibody
    • CD121a antigen antibody
    • D2S1473 antibody
    • IL 1 antibody
    • IL 1R 1 antibody
    • IL 1R alpha antibody
    • IL 1RT1 antibody
    • IL-1R-1 antibody
    • IL-1R-alpha antibody
    • IL-1RT-1 antibody
    • IL-1RT1 antibody
    • IL1 inhibitor antibody
    • IL1 Receptor I antibody
    • IL1R antibody
    • IL1R1 antibody
    • IL1R1_HUMAN antibody
    • IL1RA antibody
    • IL1RN antibody
    • IL1RT1 antibody
    • Interleukin 1 receptor alpha type 1 antibody
    • Interleukin 1 receptor antagonist protein (IRAP) antibody
    • Interleukin 1 receptor type I antibody
    • Interleukin receptor 1 antibody
    • Interleukin-1 receptor alpha antibody
    • Interleukin-1 receptor type 1 antibody
    • Interleukin-1 receptor type I antibody
    • p80 antibody
    see all

References

ab8157 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-3 of 3 Abreviews or Q&A

Answer

Thank you for your patience in this matter. The originator of ab8157 (IL1 Receptor I antibody [D14e3]) has informed us that the molecular weight (MW) of Interleukin-1 receptor type 1 is 80 kDa - this is the predicted MW weight based on the protein amino acid sequence and a band at ~80Da should be detected in WB. If you have further questions, please do not hesitate to contact us.

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Answer

All the information we have for each of our products is on the datasheet. ab8154, ab8155, ab8156 and ab8157 are four different monoclonal clones - all raised in rat - all have been shown to be suitable for WB. I am unable to advise which antibody works best in WB.

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Question
Answer

No, none of the IL-1 Receptors have yet been tested in immunocytochemistry

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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